Use lowest effective daily dose for shortest duration possible. Increased risk of serious GI adverse events eg, bleeding, ulceration, & stomach/intestine perforation; serious CV thrombotic events, MI, & stroke. Renal papillary necrosis & other renal injury on long-term use; renal toxicity if renal prostaglandins have a compensatory role in renal perfusion maintenance. Fluid retention, oedema & HTN. Elevations of ALT &/or AST. Not recommended in patients w/ advanced renal disease. Discontinue at the 1st appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. May mask fever & other signs of inflammation. Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ warfarin or other oral anticoagulants. Patients w/ renal, hepatic, or cardiac dysfunction. Patients w/ dehydration; rehydrate patients prior to starting therapy. May impair ability to drive or operate machinery. Not recommended in women attempting to conceive. Elderly.